Basics
Most Favored Nation: International Reference Pricing For Drugs
Health Care
Published on November 10, 2025
Explore This BasicIn many countries, governments are the primary or sole purchasers of drugs. As such, drug prices are largely determined by a government-negotiated price. Governments in these countries may be the only healthcare payers, and thus retain the ability to dictate the prices of medicines as a condition of drug market access and coverage. Traditionally, the United States has relied on pricing dictated by free market forces. The United States government is not the only purchaser of drugs, with the private sector making up a majority. As a result, the government has considerably less influence on the price of drugs in the United States. Some, however, have suggested changing our drug pricing system to a form of International Reference Pricing known as Most Favored Nation (MFN), where drug prices would be set based on the lowest amount paid by other countries with a Gross Domestic Product comparable to that of the United States. This basic explains the framework behind MFN for drug pricing, current regulations and legislation, and the current landscape regarding the policy.
Links to Other Resources
- Biotechnology Innovation Organization – Putting Americans First: The Cost of International Price Setting | BIO
- Commonwealth Fund – Medicare Drug Price Negotiations: All You Need to Know
- Centers for Medicare and Medicaid Services – FACT SHEET: Most Favored Nation Model for Medicare Part B Drugs and Biologicals Interim Final Rule with Comment Period
- Centers for Medicare and Medicaid Services – Most Favored Nation Model
- Charles River Associates – The impact of price controls on rare disease medicines access and lessons for the US
- Charles River Associates – By importing price levels through a most-favored-nation model, the US would risk undermining its leadership in rare disease innovation and patient access
- Distribution Alliance – HDA Statement on “Most-Favored-Nation” Executive Order
- Fox News & HHS Sec. Robert F. Kennedy Jr. – American patients pay more so others can pay less — that stops now
- PhRMA – Lessons Learned from Europe: Price Setting Policies Erode Biopharmaceutical Leadership
- PhRMA – How Will International Reference Pricing Affect You?
- PhRMA – Setting the record straight on international reference pricing
- U.S. Dept. of Health and Human Services – HHS, CMS Set Most-Favored-Nation Pricing Targets to End Global Freeloading on American Patients
- United States Congress – H.R.5376 – Inflation Reduction Act of 2022
- The White House – DELIVERING MOST-FAVORED-NATION PRESCRIPTION DRUG PRICING TO AMERICAN PATIENTS
- The White House – Fact Sheet: President Donald J. Trump Announces Actions to Get Americans the Best Prices in the World for Prescription Drugs